Whereas patients with severe level of addiction had to be maintained on buprenorphine and detoxification could not be completed with high dropout rate in tramadol groupĭiscussion: Tramadol has good efficacy in detoxification and relapse prevention in patients with moderate level of opioid dependence as compared to buprenorphine, Whereas Buprenorphine is better for maintenance treatment and is of higher clinical utility in severe level of opioid dependence where maintenance therapy is required. Results: There was statistically significant difference between the two groups in patients with moderate level of addiction with 78% of Tramadol group and 57% of the Buprenorphine group completed detoxification at the end of 12 weeks.
Flexible dosing schedule was followed and drug was titrated using (COWS) Clinical Opiate Withdrawal Scale and (CGI) Clinical Global Impression Methods: Ina randomized open label parallel group design study, 70 patients with opioid dependence with daily heroine use equal to 1-10 mg, 10-20 mg, >20 mg methadone using stratified proportionate sampling were assigned into two treatment groups i.e. , it appears to have low abuse potential and is a non-scheduled analgesic.Īim and Objective: to compare the effects and relative clinical utility of Tramadol and Buprenorphine in the treatment of heroine withdrawal in opioid dependant patients. Visit for more related articles at Journal of Addiction Research & Therapyīackground: Tramadol is an atypical centrally acting synthetic analgesic and its o-demethylated metabolite, (+)-o-demethyltramadol (known as m1), has greater affinity for the mu-opioid receptor which makes it a candidate for opiate withdrawal treatment. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Buprenorphine for the Treatment of Opioid Dependence: A Comparative Study. Received date: Accepted date: AugPublished date: August 12, 2015Ĭitation: Pahwa M, Sidhu BS, Raj R, Kumar E (2015) Tramadol vs.
Mehak Pahwa (garg)ĭepartment of Psychiatry, Government Medical College, Patiala, India Buprenorphine for the Treatment of Opioid Dependence: A Comparative Study Mehak Pahwa *, BS Sidhu, Rajnish Raj and Eish Kumarĭepartment of Psychiatry, Government Medical College, Patiala, India Corresponding Author: Dr.
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